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Comb Chem High Throughput Screen. 2019;22(4):232-237. doi: 10.2174/1386207322666190402160455.

Expression and Significance of Th17 Cells and Related Factors in Patients with Autoimmune Hepatitis.

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1
Department of Infectious Diseases, Inner Mongolia People's Hospital, Inner Mongolia 010017, China.

Abstract

OBJECTIVE:

This study aims to investigate the expression and clinical significance of Th17 cells and related factors in peripheral blood of patients with Autoimmune Hepatitis (AIH).

METHODS:

A retrospective selection of 100 patients with AIH were included as a study group, and 100 healthy volunteers in the outpatient clinic were selected as the control group. The levels of IL- 17, IL-6, IL-21 and TNF-α in peripheral blood of all subjects were detected by enzyme-linked immunosorbent assay and the frequency of Th17 cells and Treg cells was detected by flow cytometry.

RESULTS:

Results showed that the study group had higher levels of serum total bilirubin (TBil), alkaline phosphatase (ALP), γ -glutamyltranspeptidase (γ-GT), immunoglobulin G (IgG), immunoglobulin M (IgM), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) than the control group, as well as higher levels of IL-17, IL-6, IL-21 and TNF-α in serum. The frequency of Th17 cells in peripheral blood was higher in the study group, while the frequency of Treg cells was lower. Also, serum IL-17, TNF-α levels and Th17 cells frequency were positively correlated with ALT and AST, whereas Treg cells frequency were negatively correlated with ALT and AST levels.

CONCLUSION:

Our finding demonstrates that Th17 cell frequency and their related factors IL-17 and TNF-α, are associated with liver damage, which might be used to monitor AIH disease severity.

KEYWORDS:

Asia-pacific region; IL-17; TNF-α; Th17 cells; autoimmune hepatitis; liver damage.

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