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Neuron. 2019 Apr 3;102(1):91-103. doi: 10.1016/j.neuron.2019.03.022.

Uncovering the Genetic Architecture of Major Depression.

Author information

1
Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Electronic address: andrew.mcintosh@ed.ac.uk.
2
Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
3
Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK; Department of Medical and Molecular Genetics, King's College London, London UK.

Abstract

There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the care of people affected. We identify four priorities for how the field of MD genetics research may move forward in future years, namely by increasing the sample sizes available for genome-wide association studies (GWASs), greater inclusion of diverse ancestries and low-income countries, the closer integration of psychiatric genetics with electronic medical records, and the development of the neuroscience toolkit for polygenic disorders.

PMID:
30946830
PMCID:
PMC6482287
[Available on 2020-04-03]
DOI:
10.1016/j.neuron.2019.03.022
[Indexed for MEDLINE]

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