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Medicine (Baltimore). 2019 Apr;98(14):e15062. doi: 10.1097/MD.0000000000015062.

PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment.

Liu Y1,2, Wang X1, Han J3, Liu L1, Jin Y1,4, Jin L1, Ye P1.

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Department of Geriatric Cardiology, Chinese PLA General Hospital.
Critical Care Center, The 302 Hospital, People's Liberation Army.
Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an.
Geriatric Institute, Chinese PLA Air Force General Hospital, Beijing, China.


This study aimed to investigate the relationship between plasma proprotein convertase subtilisin kexin 9 (PCSK9) and small dense low-density lipoprptein (sdLDL) in diabetic and non-diabetic participants in a community-dwelling cohort.The plasma levels of PCSK9 and sdLDL were detected in 1766 participants (median age: 61.40 years; 733 males vs 1033 females; 383 diabetic vs 1383 non-diabetic patients) from the Pingguoyuan community of Beijing, China.Results showed that Pearson correlation analysis revealed a positive correlation between PCSK9 and sdLDL (r = 0.263, P < .001). Multiple linear regression analysis showed a significant positive correlation between plasma PCSK9 and sdLDL in the whole population study. sdLDL was used as the dependent variable, and the potential cofounders were adjusted. However, any independent relationship was not observed between circulating PCSK9 and sdLDL in the diabetic subpopulation (r = 0.269, P < .05, β = 9.591, P > .05).Thus, there is a positive correlation between plasma PCSK9 and sdLDL in a community-dwelling cohort, but not in type 2 diabetic subpopulation, after confounder adjustment.

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