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J Clin Transl Hepatol. 2019 Mar 28;7(1):86-92. doi: 10.14218/JCTH.2018.00042. Epub 2019 Mar 25.

Mechanisms of Hepatic Cholestatic Drug Injury.

Author information

1
Department of Pharmacology, Faculty of Medicine Osijek, Osijek, Croatia.
2
Department of Pharmacology, Faculty of Dental Medicine and Health, Osijek, Croatia.
3
Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.

Abstract

Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.

KEYWORDS:

Bile acids; Cholestasis; Drug-induced liver injury

Conflict of interest statement

The authors have no conflict of interests related to this publication.

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