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Dose Response. 2019 Mar 28;17(1):1559325819828623. doi: 10.1177/1559325819828623. eCollection 2019 Jan-Mar.

Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model.

Author information

1
Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
2
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
3
Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
4
Department of Biochemistry and Molecular Cell Biology, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
5
Department of Radiation Oncology, Monmouth Medical Center, Barnabas Health, Long Branch, NJ, USA.
6
Department of Nuclear Accident Medical Emergency, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
7
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu, People's Republic of China.
8
Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou, Jiangsu, People's Republic of China.
9
Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
10
College of Medical Technology and Engineering, Fujian Medical University, Fuzhou, People's Republic of China.

Abstract

The study aimed to develop a novel dose conversion platform by improving linear-quadratic (LQ) model to more accurately describe radiation response for high fraction/acute doses. This article modified the LQ model via piecewise fitting the biological dose curve using different fractionated dose and optimizing the consistency between mathematical model and experimental data to gain a more reasonable transform. That mathematical development of the LQ model further amended certain deviations of various cell curves with high doses and implied the rationality of the present model at low dose range. The modified biologically effective dose model that solved the dilemma of inaccurate LQ model had been used in comparing between hypofractionated and conventional fractioned dose. It has been verified that the calculated values are similar in the treatment of same efficacy, no matter what α/β is, and provided a more rational explanation for significant differences among various hypofractionations. The equivalent uniform dose based on the subsection function could represent arbitrary inhomogeneous dose distributions including high-dose fractions, providing a foundation for the implementation of detailed evaluation of different cell dose effects.

KEYWORDS:

biologically effective dose (BED); dose conversion; equivalent uniform dose (EUD); linear-quadratic (LQ) model; stereotactic body radiation therapy (SBRT)

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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