Format

Send to

Choose Destination
J Perinatol. 2019 Sep;39(9):1213-1218. doi: 10.1038/s41372-019-0368-z. Epub 2019 Apr 3.

Cefazolin pharmacokinetics in premature infants.

Author information

1
Duke Clinical Research Institute, Durham, NC, USA.
2
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
3
Escola Paulista de Medicina-Universidade Federal de São Paulo, São Paulo, Brazil.
4
UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
5
Novant Health Medical Group, Charlotte, NC, USA.
6
Duke Clinical Research Institute, Durham, NC, USA. michael.cohenwolkowiez@duke.edu.
7
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. michael.cohenwolkowiez@duke.edu.

Abstract

OBJECTIVE:

Pharmacokinetic (PK) data to guide cefazolin dosing in premature infants are virtually non-existent. Therefore, we aimed to characterize cefazolin PK in infants aged ≤32 weeks of gestation at birth.

STUDY DESIGN:

We conducted a prospective, open-label PK and safety study of cefazolin in infants ≤32 weeks gestation from a University Medical Center. We administered intravenous cefazolin and collected both timed and scavenged blood samples. We analyzed data using non-linear mixed effect modeling and simulated several dosage regimens to achieve target concentrations against methicillin-susceptible Staphylococcus aureus.

RESULTS:

We analyzed 40 samples from nine infants and observed that premature infants had lower clearance and greater volume of distribution for cefazolin compared to older children. The median (range) individual Bayesian estimates were 0.03 L/h/kg (0.01-0.08) for clearance and 0.39 L/kg (0.31-0.52) for volume.

CONCLUSION:

Simulations suggested reduced cefazolin dosing based on postmenstrual age achieve target concentrations and potentially reduce unnecessary exposure.

PMID:
30944398
PMCID:
PMC6713589
[Available on 2019-10-03]
DOI:
10.1038/s41372-019-0368-z

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center