Format

Send to

Choose Destination
Endocr J. 2019 May 28;66(5):443-450. doi: 10.1507/endocrj.EJ18-0466. Epub 2019 Apr 2.

Comparison of therapeutic effects of acarbose and metformin under different β-cell function status in Chinese patients with type 2 diabetes.

Author information

1
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P. R. of China.
2
Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, P. R. of China.
3
Department of Endocrinology, Huai-Rou Hospital, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 101400, P. R. of China.

Abstract

MARCH study suggested that acarbose had similar therapeutic effect on glycated hemoglobin reduction compared to metformin in newly diagnosed type 2 diabetes patients as initial therapy in China. We aimed to investigate whether the efficacy of acarbose was still similar to metformin under different β-cell function status. According to the homeostasis model assessment (HOMA)-β level, 670 patients were divided into better β-cell function group, medium β-cell function group and poor β-cell function group. Patients received acarbose 300 mg/d or metformin 1,500 mg/d for 48 weeks. We found both acarbose and metformin could decrease glycated hemoglobin to similar levels after 48 weeks treatment in all groups. In medium β-cell function group, the decrease of fasting blood glucose after metformin treatment was more significant compared to acarbose (p = 0.040); however, the decrease of post-challenge blood glucose after acarbose treatment was more significant compared to metformin (p = 0.020). Moreover, in poor β-cell function group, the decrease of body weight and body mass index after acarbose treatment were significant compared to metformin (p = 0.004 and p = 0.031, respectively). Therefore, acarbose contributed a similar therapeutic effect to plasma glucose control compared to metformin treatment, even under different β-cell function status.

KEYWORDS:

Acarbose; Chinese; Metformin; Type 2 diabetes; β-cell function

PMID:
30944269
DOI:
10.1507/endocrj.EJ18-0466
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center