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Ann Pediatr Endocrinol Metab. 2019 Mar;24(1):68-70. doi: 10.6065/apem.2019.24.1.68. Epub 2019 Mar 31.

A case of immune-mediated type 1 diabetes mellitus due to congenital rubella ınfection.

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Division of of Pediatric Endocrinology, Balıkesir Atatürk State Hospital, Balıkesir, Turkey.
Child and Adolescent Psychiatry Unit, Dokuz Eylul University Hospital, Izmir, Turkey.


Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and severe fetal injury. It has been shown that type 1 diabetes mellitus develops in 12%-20% of patients with congenital rubella infection, and disorders in the oral glucose tolerance test is observed in 40% of patients. No biochemical or serological markers exist which could indicate that type 1 diabetes was caused by a congenital rubella infection. We report a 13-year-old male patient who was admitted to our hospital with complaints of new-onset polyuria, polydipsia, urination, and weight loss. In addition, he was found to have neurosensory hearing loss, patent ductus arteriosus, and microcephaly. Immunemediated type 1 diabetes mellitus was considered due to the fact that the autoantibodies of diabetes mellitus were positive.


Diabetes; Hearing loss; Rubella

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