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Dermatol Ther. 2019 May;32(3):e12888. doi: 10.1111/dth.12888. Epub 2019 Apr 17.

Anti-aging and hydration efficacy of a cross-linked hyaluronic acid microstructure patch.

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Department of Dermatology, Kyunghee University hospital at Gangdong, Seoul, Republic of South Korea.
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of South Korea.


This study evaluated the safety and efficacy of biodegradable microstructure patches composed of cross-linked hyaluronic acid (CLHA). A primary skin irritation test showed that the CLHA patches were not an irritant, whereas a clinical study showed that application of single CLHA patches significantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days. Patch application also improved superficial wrinkles at the periorbital region for 3 days and at the nasolabial fold for 1 day. The absence of side effects indicated that application of these CLHA microstructure patches is both safe and convenient for moisturization and anti-wrinkle effects.


anti-aging; hyaluronic acid; microstructure patch


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