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Chin J Physiol. 2019 Jan-Feb;62(1):27-34. doi: 10.4103/CJP.CJP_10_18.

Modulation of glycinergic inhibition on respiratory rhythmic hypoglossal bursting in the rat.

Author information

1
Department of Biological Sciences, College of Science, National Sun Yat-sen University; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan.
2
Department of Life Science, College of Science, National Taiwan Normal University, Taipei, Taiwan.

Abstract

The hypoglossal nerve displays respiratory rhythmic bursting and is composed of preinspiratory and inspiratory activity which is important in maintaining upper airway patency. The present study was designed to examine the modulatory role of glycinergic inhibition in respiratory rhythmic hypoglossal bursting. The activity of the phrenic nerve, as well as the medial and lateral branches of the hypoglossal nerve, was recorded simultaneously in urethane-anesthetized and mechanically ventilated adult rats in response to moderate and high levels of sustained lung inflation. The results demonstrated that inspiratory activity of the phrenic nerve gradually reduced with increasing lung inflation. The burst amplitude and discharge onset of the hypoglossal nerve branches were enhanced during moderate lung inflation but inhibited by high levels of lung inflation. These lung volume-mediated respiratory reflexes were abolished following a bilateral cervical vagotomy. In addition, intravenous administration of a glycine receptor antagonist (strychnine, 1 ╬╝mole/kg) attenuated preceding onset of rhythmic hypoglossal bursting but enhanced inspiratory hypoglossal burst amplitude during the baseline. Moreover, both excitatory and inhibitory effects of lung inflation on hypoglossal nerve activity were attenuated following a glycine transmission blockade. These results suggest that glycinergic inhibition modulated rhythmic hypoglossal bursting and was involved in mediating lung volume-induced respiratory reflexes.

KEYWORDS:

Glycinergic inhibition; hypoglossal; lung inflation

PMID:
30942196
DOI:
10.4103/CJP.CJP_10_18
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