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J BUON. 2019 Jan-Feb;24(1):354-367.

Association between HOTAIR polymorphisms and cancer risk:a meta-analysis based on twenty-one case-control studies.

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Organ Transplant Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan, P.R. China.



Previous studies have identified the association between single nucleotide polymorphisms (SNPs) of long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) and various cancers risk. Herein,we conducted a meta-analysis to investigate the effects of HOTAIR polymorphisms on multiple cancers risk.


Relevant studies published from July 2014 to October 2017 were identified in the PubMed, EmBase and Web of Science databases. A total of 21 studies including 13,675 cases and 16,306 controls were selected, and the genotypes were mainly confirmed by TaqMan allelic discrimination and PCR-RFLP. Meta-analysis was conducted by STATA 12.0 software and odds ratios (ORs) with their 95% confidence interval (95% CI) were used to estimate the associations between HOTAIR polymorphisms and multiple cancers risk.


Twenty-one case-control studies with 13,675 cases and 16,306 controls met our inclusion criteria. Our results showed a significant association between HOTAIR rs920778 polymorphism and increased cancer risk under all five genetic models, as well as in Asians subgroup analysis based on ethnicity, digestive and gynecologic cancer group based on cancer type. For rs12826786 C>T polymorphism, we found a similarly increased risk in Asians group under the allele, dominant, homozygote and recessive models.


Our findings indicate that the T allele or TT genotype of HOTAIR polymorphisms may serve as a potential genetic marker for cancer risk, especially in Asians. However, there is no significant association between SNPs variants and cancer risk under any five genetic models for rs4759314, rs1899663 and rs874945.


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