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J BUON. 2019 Jan-Feb;24(1):347-353.

Potential of utilization of albumin as a delivery module in cancer model.

Author information

1
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Haidian District, Tsinghua East Street, Beijing 100084, People's Republic of China.

Abstract

PURPOSE:

This study compared the potential of 2 nanoparticles, namely albumin and gold nanoparticles, for the specific delivery of 99mTC- resveratrol in colon cancer. The aim of adding radioactive tag (99mTC) to resveratrol was to utilize it for imaging purposes.

METHODS:

We compared the potential of albumin loaded 99mTC- resveratrol with gold nanoparticles loaded 99mTc-resveratrol for tumor specific delivery. Twenty male Wistar rats were used for the formation of colon cancer model. Both delivery molecules were tested for tumor specific delivery.

RESULTS:

The results showed efficient delivery of 99mTC-resveratrol with albumin in comparison to gold nanoparticles, as confirmed by single-photon emission computed tomography (SPECT).

CONCLUSIONS:

Albumin is a superior molecule for the efficient delivery of 99mTC- resveratrol at tumor sites in comparison to gold nanoparticles.

PMID:
30941991

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