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J BUON. 2019 Jan-Feb;24(1):143-149.

Hepatic arterial infusion in liver tumors of unknown, uncertain or unusual primary: single-center experience.

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Fourth Department of Medicine, Charles University Medical School Teaching Hospital, Hradec Kralove, Czech Republic.



The aim of the present study was to analyze a single-center experience with hepatic arterial infusion (HAI) in patients with unknown or uncertain primary or tumors not usually treated with HAI.


A retrospective analysis of 14 patients treated between 1996 and 2003 for liver tumors of unknown, uncertain or unusual primary was performed.


All patients were treated with HAI combination regimens based on 5-fluorouracil and folinic acid. The response was not evaluable in most patients, predominantly because of only a single course of therapy could be administered and no cases of partial or complete response were noted. The median survival of all patients was 6.6 months (5-year survival 14%).


The present data demonstrate limited efficacy of HAI in patients with liver tumors of unknown, uncertain or unusual primary. HAI should not be offered to these patients.


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