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IUBMB Life. 2019 Jun;71(6):749-759. doi: 10.1002/iub.2040. Epub 2019 Apr 2.

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals.

Author information

1
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
2
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
3
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
4
Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Abstract

Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites.

KEYWORDS:

Fam20C; bacterial effectors; parasite kinases; protein kinases; secretory pathway

PMID:
30941842
DOI:
10.1002/iub.2040

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