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J Anim Physiol Anim Nutr (Berl). 2019 May;103(3):868-881. doi: 10.1111/jpn.13084. Epub 2019 Apr 2.

Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra-uterine growth-retarded suckling piglets.

Author information

1
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
2
Postdoctoral Research Station of Clinical Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
3
Postdoctoral Research Station of Food Science and Engineering, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China.
4
Evonik Degussa (China) Co., Ltd, Beijing, China.
5
Evonik Nutrition & Care GmbH, Hanau, Germany.

Abstract

This study investigated the effects of dietary supplementation with L -methionine (L -Met), DL -methionine (DL -Met) and calcium salt of the methionine hydroxyl analog (MHA-Ca) on growth performance, intestinal morphology, antioxidant capacity and immune function in intra-uterine growth-retarded (IUGR) suckling piglets. Six normal birthweight (NBW) female piglets and 24 same-sex IUGR piglets were selected at birth. Piglets were fed nutrient adequate basal diet supplemented with 0.08% L -alanine (NBW-CON), 0.08% L -alanine (IUGR-CON), 0.12% L -Met (IUGR-LM), 0.12% DL -Met (IUGR-DLM) and 0.16% MHA-Ca (IUGR-MHA-Ca) from 7 to 21 days of age respectively (n = 6). The results indicated that IUGR decreased average daily milk (dry matter) intake and average daily gain and increased feed conversion ratio of suckling piglets (p < 0.05). Compared with the NBW-CON piglets, IUGR also impaired villus morphology and reduced antioxidant capacity and immune homeostasis in the intestine of IUGR-CON piglets (p < 0.05). Supplementation with L -Met enhanced jejunal villus height (VH) and villus area and ileal VH of IUGR piglets compared with IUGR-CON piglets (p < 0.05). Similarly, DL -Met supplementation increased VH and the ratio of VH to crypt depth in the jejunum compared with IUGR-CON pigs (p < 0.05). Supplementation with L -Met and DL -Met (0.12%) tended to increase reduced glutathione content and reduced glutathione: oxidized glutathione ratio and decrease protein carbonyl concentration in the jejunum of piglets when compared with the IUGR-CON group (p < 0.10). However, supplementation with MHA-Ca had no effect on the intestinal redox status of IUGR piglets (p > 0.10). In conclusion, supplementation with either L -Met or DL -Met has a beneficial effect on the intestinal morphology and antioxidant capacity of IUGR suckling piglets.

KEYWORDS:

antioxidant capacity; immune function; intestinal morphology; intra-uterine growth retardation; methionine; piglet

PMID:
30941824
DOI:
10.1111/jpn.13084

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