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Nat Commun. 2019 Apr 2;10(1):1489. doi: 10.1038/s41467-019-09373-w.

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology.

Author information

1
Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
2
Texas A&M University, College Station, TX, 77840, USA.
3
Laboratory of Genetic Susceptibility, National Cancer Institute, National Institutes of Health, Rockville, MD, 20850, USA.
4
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
5
Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA. eostrand@mail.nih.gov.

Abstract

Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide and small indels, creating a large catalog of genomic variation for a companion animal species. We undertake both selective sweep analyses and genome wide association studies (GWAS) inclusive of over 144 modern breeds, 54 wild canids and a hundred village dogs. Our results identify variants of strong impact associated with 16 phenotypes, including body weight variation which, when combined with existing data, explain greater than 90% of body size variation in dogs. We thus demonstrate that GWAS and selection scans performed with WGS are powerful complementary methods for expanding the utility of companion animal systems for the study of mammalian growth and biology.

PMID:
30940804
PMCID:
PMC6445083
DOI:
10.1038/s41467-019-09373-w
[Indexed for MEDLINE]
Free PMC Article

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