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Oncol Res. 2019 Apr 2. doi: 10.3727/096504018X15482423944678. [Epub ahead of print]

Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells.

Cai Y1,2,3, Zhang C1,2,3, Zhan L1,2, Cheng L1,2, Lu D1,2,4, Wang X1,2, Xu H5, Wang S6, Wu D1,2, Ruan L4.

Author information

1
Clinical Medical College of Hubei University of Chinese Medicine, Wuhan 430065, China.
2
Department of Hepatology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430060, China.
3
Hubei Province Academy of Traditional Chinese Medicine, Wuhan 430060, China.
4
Infectious disease of Wuhan Medical Treatment Center, Wuhan 430040, China.
5
College of Pharmacy of Hubei University of Chinese Medicine, Wuhan 430062, China.
6
Wuhan Hospital of Traditional Chinese Medicine Department of Pediatrics, Wuhan 430014, China.

Abstract

The thorns of Gleditsia sinensis have been historically used in Chinese medicine, and considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and still requires the development of new drugs with higher efficiency. By using a rat HCC model implanted with cancerous Walker-256 cells, the therapeutic effects of Gleditsia sinensis extract (GSE) were assessed, as well as its regulatory effects on miRNAs. GSE significantly restored liver morphology and dramatically induced cell apoptosis in HCC rats. In addition, miR-21/181b/183 was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and sorafenib. PTEN/TIMP3/PDCD4 down-regulation was consistent with the targets of miR36 21/181b/183 in the HCC liver, and the alteration of these target genes was restored by both GSE and sorafenib. TIMP3 effects on MMP-2/9 expression were also determined. Our present findings indicate the potential of GSE in HCC treatment, and expand the understanding of miRNA-related mechanisms in the anticancer effects of GSE.

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