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Orthopade. 2019 Sep;48(9):784-791. doi: 10.1007/s00132-019-03711-y.

Efficacy of platelet-rich plasma injections for treating Achilles tendonitis : Systematic review of high-quality randomized controlled trials.

Author information

1
Department of Hand-foot and Microsurgery 2, The 2nd affiliated Hospital, Inner Mongolia Medical University, No. 1 Yingfang Street, 010030, Hyumin District, Hohhot, Inner Mongolia, China.
2
Department of Orthopedics, Hebei Chest Hospital, 050000, Shijiazhuang, Hebei Province, China.
3
Department of Arthroscopy and Sports Medicine, The 2nd affiliated Hospital, Inner Mongolia Medical University, No. 1 Yingfang Street, 010030, Hyumin District, Hohhot, Inner Mongolia, China.
4
Department of Neurology, The Second Hospital, Hebei Medical University, No. 215, Heping West Road, 050000, Xinhua District, Shijiazhuang, Hebei Province, China.
5
Department of Arthroscopy and Sports Medicine, The 2nd affiliated Hospital, Inner Mongolia Medical University, No. 1 Yingfang Street, 010030, Hyumin District, Hohhot, Inner Mongolia, China. yanshi2017@163.com.
6
Department of Hand-foot and Microsurgery 2, The 2nd affiliated Hospital, Inner Mongolia Medical University, No. 1 Yingfang Street, 010030, Hyumin District, Hohhot, Inner Mongolia, China. wyzkyzy@163.com.

Abstract

BACKGROUND:

The Achilles tendon is the coarsest tendon in the body. Achilles tendonitis is relatively common and its incidence is increasing.

PURPOSE:

To evaluate the efficacy of platelet-rich plasma (PRP) injections for treating Achilles tendonitis.

METHODS:

A literature search was carried out in the Cochrane Library Central Register of Controlled Trials (2017), PubMed (January 1976-March 2017) and EMBASE (January 1976-March 2017) databases to retrieve the available clinical evidence for PRP in the treatment of Achilles tendon lesions for a systematic review. The inclusion criteria were (1) conservative PRP treatment of Achilles tendon inflammation in a randomized controlled trial (RCT), (2) level I clinical research evidence and (3) published in English. The exclusion criteria were (1) unclear experimental methods and data and (2) PRP treatment of other diseases.

RESULTS:

A total of 4 articles involving 152 cases were included in the analysis. The mean age of subjects was 49 years. Data on the Victorian Institute of Sport Assessment-Achilles (VISA-A) score, color Doppler ultrasound index and recovery time to normal exercise were extracted. There were no significant differences between the treatment groups and control groups following the PRP injections.

CONCLUSION:

The lack of differences between data from the control group and the patient groups included in the studies may be related to the difficulty of performing a randomized controlled trial (RCT). A strong basis for using PRP to treat Achilles tendonitis was not found, although PRP has important clinical significance for treating Achilles tendonitis.

KEYWORDS:

Color Doppler ultrasonography; Fibroblasts; Meta-analysis; Regeneration; Vascular endothelial growth factor

PMID:
30937491
DOI:
10.1007/s00132-019-03711-y
[Indexed for MEDLINE]

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