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Ther Adv Chronic Dis. 2019 Mar 26;10:2040622319837851. doi: 10.1177/2040622319837851. eCollection 2019.

Barrett's esophagus: novel strategies for screening and surveillance.

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Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Esophageal Center, Department of Gastroenterology and Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.


Barrett's esophagus is the precursor lesion for esophageal adenocarcinoma. Screening and surveillance of Barrett's esophagus are undertaken with the goal of earlier detection and lowering the mortality from esophageal adenocarcinoma. The widely used technique is standard esophagogastroduodenoscopy with biopsies per the Seattle protocol for screening and surveillance of Barrett's esophagus. Surveillance intervals vary depending on the degree of dysplasia with endoscopic eradication therapy confined to patients with Barrett's esophagus and confirmed dysplasia. In this review, we present various novel techniques for screening of Barrett's esophagus such as unsedated transnasal endoscopy, cytosponge with trefoil factor-3, balloon cytology, esophageal capsule endoscopy, liquid biopsy, electronic nose, and oral microbiome. In addition, advanced imaging techniques such as narrow band imaging, dye-based chromoendoscopy, confocal laser endomicroscopy, volumetric laser endomicroscopy, and wide-area transepithelial sampling with computer-assisted three-dimensional analysis developed for better detection of dysplasia are also reviewed.


Barrett’s esophagus; cytosponge; dysplasia; esophageal adenocarcinoma; gastroesophageal reflux disease; screening; surveillance; trefoil factor; unsedated transnasal endoscopy

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Conflict of interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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