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Asian J Neurosurg. 2019 Jan-Mar;14(1):266-268. doi: 10.4103/ajns.AJNS_252_17.

Spontaneous Carotid Cavernous Fistula in Young Female with Anti-thrombin III Deficiency.

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Department of General Medicine, MES Medical College, Malappuram, Kerala, India.


A 27-year-old female patient presented with headache, vomiting, and visual disturbances who was evaluated and detected to have a direct carotid cavernous fistula (CCF). Secondary causes were ruled out, and she was treated with coil occlusion and glue injection. A month after almost complete clinical recovery, she developed deep vein thrombosis of left thigh. Subsequent work-up revealed antithrombin III (ATIII) deficiency in her. To the best of our knowledge, this is the first reported case of ATIII deficiency associated with CCF. This case shows the importance of working up for a primary etiology if any, to prevent further complications after surgery.


Antithrombin III deficiency; carotid cavernous fistula; deep vein thrombosis; sinus thrombosis

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