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Complement Ther Med. 2019 Apr;43:49-52. doi: 10.1016/j.ctim.2019.01.003. Epub 2019 Jan 8.

Timing of oral feeding changes in premature infants who underwent osteopathic manipulative treatment.

Author information

1
NICU - Woman and Child Department, Del Ponte Hospital, Varese, Italy; Manima, Non-Profit Organization Social Assistance and Healthcare, Milan, Italy; Research Department, SOMA, Istituto Osteopatia Milano, Milan, Italy. Electronic address: lucavisma@hotmail.com.
2
Research Department, SOMA, Istituto Osteopatia Milano, Milan, Italy; NICU - Department of Pediatrics, Ospedale dei Bambini "V.Buzzi", Milan, Italy. Electronic address: andreamanzotti@soma-osteopatia.it.
3
Manima, Non-Profit Organization Social Assistance and Healthcare, Milan, Italy; Research Department, SOMA, Istituto Osteopatia Milano, Milan, Italy. Electronic address: andrea.tarantino16@gmail.com.
4
NICU - Woman and Child Department, Del Ponte Hospital, Varese, Italy. Electronic address: giuliana.bianchi@asst-settelaghi.it.
5
C.U.S.S.B, University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: nonis.alessandro@hsr.it.
6
Research Department, SOMA, Istituto Osteopatia Milano, Milan, Italy; NICU - Department of Pediatrics, Ospedale dei Bambini "V.Buzzi", Milan, Italy. Electronic address: globulo.scric@tiscali.it.
7
Research Department, SOMA, Istituto Osteopatia Milano, Milan, Italy; NICU - Department of Pediatrics, Ospedale dei Bambini "V.Buzzi", Milan, Italy. Electronic address: lombardi.fisio@gmail.com.
8
NICU - Department of Pediatrics, Ospedale dei Bambini "V.Buzzi", Milan, Italy. Electronic address: gianluca.lista@asst-fbf-sacco.it.
9
NICU - Woman and Child Department, Del Ponte Hospital, Varese, Italy. Electronic address: massimo.agosti@asst-settelaghi.it.

Abstract

BACKGROUND:

The delayed transition from gavage-to-nipple feeding is one of the most significant factors that may prolong hospital length of stay (LOS). Osteopathic manipulative treatment (OMT) has been demonstrated to be effective regarding LOS reduction, but no investigations have documented its clinical validity for attaining oral feeding.

OBJECTIVES:

To assess OMT utility regarding the timing of oral feeding in healthy preterm infants.

DESIGN:

Preliminary propensity score-matched retrospective cohort study.

SETTING:

Data were extrapolated from the neonatal intensive care unit (NICU) of Del Ponte Hospital in Varese, Italy, during the period between March 2012 and December 2013.

INTERVENTIONS:

Two propensity score-matched groups of healthy preterm infants aged 28+0 to 33+6 were compared, observing those supported with OMT until hospital discharge and control subjects.

MAIN OUTCOME MEASURES:

Days from birth to the attainment of oral feeding was the primary endpoint. Body weight, body length, head circumference and LOS were considered as secondary endpoints.

RESULTS:

Seventy premature infants were included in the study as the control group (n = 35; body weight (BW) = 1457.9 ± 316.2 g; gestational age (GA) = 31.5 ± 1.73 wk) and the osteopathic group (n = 35; BW = 1509.6 ± 250.8 g; GA = 31.8 ± 1.64 wk). The two groups had analogous characteristics at study entry. In this cohort, we observed a significant reduction in TOF (-5.00 days; p = 0.042) in the osteopathic group with a greater effect in very low birth weight infants.

CONCLUSIONS:

These data demonstrate the utility and potential efficacy of OMT for the attainment of oral feeding. Further adequately powered clinical trials are recommended.

KEYWORDS:

Fascia; Length of stay; Neonatal intensive care unit; Osteopathic medicine; Sympathetic nervous system

PMID:
30935554
DOI:
10.1016/j.ctim.2019.01.003
[Indexed for MEDLINE]

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