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Nutrients. 2019 Mar 29;11(4). pii: E741. doi: 10.3390/nu11040741.

Total Dairy, Cheese and Milk Intake and Arterial Stiffness: A Systematic Review and Meta-Analysis of Cross-sectional Studies.

Author information

1
Universidad de Castilla-La Mancha, Centro de Estudios Socio-Sanitarios, 16071 Cuenca, Spain. ana.diez@uclm.es.
2
Universidad de Castilla-La Mancha, Facultad de Enfermería, 16071 Cuenca, Spain. ana.diez@uclm.es.
3
Universidad de Castilla-La Mancha, Centro de Estudios Socio-Sanitarios, 16071 Cuenca, Spain. Celia.alvarezbueno@uclm.es.
4
Universidad de Castilla-La Mancha, Facultad de Enfermería, 16071 Cuenca, Spain. Celia.alvarezbueno@uclm.es.
5
Universidad de Castilla-La Mancha, Centro de Estudios Socio-Sanitarios, 16071 Cuenca, Spain. Vicente.martinez@uclm.es.
6
Universidad Autónoma de Chile, Facultad de Ciencias de la Salud, Talca 1670, Chile. Vicente.martinez@uclm.es.
7
Department of Environmental Health, Harvard TH Chan School of Public health, Harvard Medical School, Boston, MA 02115, USA. sotospri@ohio.edu.
8
Department of Food Sciences and Nutrition, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701, USA. sotospri@ohio.edu.
9
Diabetes Institute, Ohio University, Athens, OH 45701, USA. sotospri@ohio.edu.
10
Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center. Health Service of Castilla y León (SACYL), Primary Care Prevention and Health Promotion Research Network (REDIAPP), 37007, Salamanca, Spain. donrecio@gmail.com.
11
Departamento Enfermería y Fisioterapia. Universidad de Salamanca, 37007 Salamanca, Spain. donrecio@gmail.com.
12
Universidad de Castilla-La Mancha, Centro de Estudios Socio-Sanitarios, 16071 Cuenca, Spain. Ivan.Cavero@uclm.es.
13
Universidad de Castilla-La Mancha, Facultad de Enfermería, 16071 Cuenca, Spain. Ivan.Cavero@uclm.es.

Abstract

The aim of this review was to determine the relationship between dairy product consumption and arterial stiffness, measured by pulse wave velocity (PWV). We systematically searched the Medline, Embase and Web of Science databases until 30th January 2019 for cross-sectional data from studies addressing the association between dairy product consumption and PWV. This study was registered with PROSPERO (CRD42018110528). Both the inverse-variance fixed effects method and the DerSimonian and Laird method were used to compute pooled estimates of effect size (ES) and the respective 95% confidence intervals (CIs). Seven studies were included in the meta-analysis, with a total of 16,443 patients. Total dairy product (ES = -0.03; 95% CI [-0.04, -0.01]) and cheese (ES = -0.04; 95% CI [-0.07, -0.01]) consumption were weak, but significantly associated with lower PWV levels. Conversely, milk intake showed no significant association with PWV (ES = 0.02; 95% CI [-0.01, 0.05]). Heterogeneity in the ES was not important for the three groups of dairy products assessed. This systematic review and meta-analysis of seven studies found no detrimental effects of dairy product consumption on arterial stiffness measured by PWV. Due to the scarcity of studies, further investigations are warranted to clarify the role of dairy products on arterial stiffness.

KEYWORDS:

arterial stiffness; dairy product; meta-analysis; milk; pulse wave velocity; systematic review

PMID:
30934969
PMCID:
PMC6520823
DOI:
10.3390/nu11040741
[Indexed for MEDLINE]
Free PMC Article

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