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Int J Mol Sci. 2019 Mar 29;20(7). pii: E1576. doi: 10.3390/ijms20071576.

Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis.

Zhang J1,2,3, Zhou Y4,5,6, Tang PMK7, Cheng ASL8, Yu J9,10, To KF11,12,13, Kang W14,15,16.

Author information

1
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zhangjinglin987@gmail.com.
2
Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zhangjinglin987@gmail.com.
3
Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zhangjinglin987@gmail.com.
4
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zyhjoe@gmail.com.
5
Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zyhjoe@gmail.com.
6
Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China. zyhjoe@gmail.com.
7
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. patrick.tang@cuhk.edu.hk.
8
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China. alfredcheng@cuhk.edu.hk.
9
Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. junyu@cuhk.edu.hk.
10
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China. junyu@cuhk.edu.hk.
11
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. kfto@cuhk.edu.hk.
12
Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. kfto@cuhk.edu.hk.
13
Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China. kfto@cuhk.edu.hk.
14
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. weikang@cuhk.edu.hk.
15
Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China. weikang@cuhk.edu.hk.
16
Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China. weikang@cuhk.edu.hk.

Abstract

The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain transcription regulator 1 (TAZ), two transcriptional co-activators with a PDZ-binding motif, function as critical effectors negatively regulated by the Hippo pathway. Previous studies indicate the involvement of YAP1/TAZ in mechanotransduction by crosstalking with the extracellular matrix (ECM) and the F-actin cytoskeleton associated signaling network. In gastric cancer (GC), YAP1/TAZ functions as an oncogene and transcriptionally promotes tumor formation by cooperating with TEAD transcription factors. Apart from the classic role of Hippo-YAP1 cascade, in this review, we summarize the current investigations to highlight the prominent role of YAP1/TAZ as a mechanical sensor and responder under mechanical stress and address its potential prognostic and therapeutic value in GC.

KEYWORDS:

F-actin; Hippo pathway; YAP1; gastric cancer; mechanical strain

PMID:
30934860
PMCID:
PMC6480114
DOI:
10.3390/ijms20071576
[Indexed for MEDLINE]
Free PMC Article

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