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Environ Pollut. 2019 Jun;249:758-766. doi: 10.1016/j.envpol.2019.03.054. Epub 2019 Mar 21.

Associations between concentrations of perfluoroalkyl substances in human plasma and maternal, infant, and home characteristics in Winnipeg, Canada.

Author information

1
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: clare.elizabeth.mc@gmail.com.
2
Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
3
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
4
Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
5
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
6
Department of Pediatrics, Child & Family Research Institute, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
7
Department of Pediatrics & Physiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
8
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
9
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
10
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Environmental Studies and Sciences, The University of Winnipeg, Richardson College for the Environment, Winnipeg, Manitoba, Canada; Department of Chemistry, The University of Winnipeg, Richardson College for the Environment, Winnipeg, Manitoba, Canada.

Abstract

Perfluoroalkyl substances (PFASs) are known to be toxic, bioaccumulative, and persistent. However, exposure routes and toxic effects to humans are still widely unknown. Our objectives were to evaluate potential correlations between concentrations of PFASs in maternal plasma and infant cord blood with home characteristics and developmental effects, including wheezing. The concentrations of 17 PFASs were measured in plasma from prenatal women (n = 414), postnatal women (n = 247), and cord blood (n = 50) from a subset of participants in a population-based birth cohort in Winnipeg, Manitoba, Canada, using online solid phase extraction (SPE) with liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Multiple linear regression and principal component analysis (PCA) were used to evaluate possible associations with PFAS concentrations. Surveys were used to collect information regarding maternal characteristics (e.g. age, parity, duration of breastfeeding), infant characteristics (e.g. birth weight, birth length, head circumference, gestational age, and incidence of recurrent wheezing), and home characteristics (e.g. home age,carpet coverage in the most used room, presence of new furniture, or recent home renovations). PFASs in plasma were associated with maternal characteristics but not home characteristics or early childhood wheezing. PFASs were not associated with developmental effects, with the exception that perfluoroundecanoic acid (PFUA) was negatively associated with birth weight. Further studies investigating the potential influences of PFUA on birth weight are warranted.

KEYWORDS:

Blood; Developmental effects; Liquid chromatography; Perfluoroalkyl substances

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