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J Cell Mol Med. 2019 Jun;23(6):3784-3794. doi: 10.1111/jcmm.14292. Epub 2019 Apr 1.

iPSCs: A powerful tool for skeletal muscle tissue engineering.

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Departamento de Bioquímica, Facultad de Medicina, Instituto de Investigaciones Biomédicas "Alberto Sols", Universidad Autónoma de Madrid, Spain, (UAM-CSIC), Madrid, Spain.
Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
Grupo de Investigación, Traslacional con células iPS, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.
Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain.


Both volumetric muscle loss (VML) and muscle degenerative diseases lead to an important decrease in skeletal muscle mass, condition that nowadays lacks an optimal treatment. This issue has driven towards an increasing interest in new strategies in tissue engineering, an emerging field that can offer very promising approaches. In addition, the discovery of induced pluripotent stem cells (iPSCs) has completely revolutionized the actual view of personalized medicine, and their utilization in skeletal muscle tissue engineering could, undoubtedly, add myriad benefits. In this review, we want to provide a general vision of the basic aspects to consider when engineering skeletal muscle tissue using iPSCs. Specifically, we will focus on the three main pillars of tissue engineering: the scaffold designing, the selection of the ideal cell source and the addition of factors that can enhance the resemblance with the native tissue.


biomaterials; iPS-skeletal muscle; iPSCs; induced pluripotent stem cells; personalized medicine; regenerative medicine; scaffold; tissue engineering; volumetric muscle loss

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