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J Vet Pharmacol Ther. 2019 Apr 1. doi: 10.1111/jvp.12760. [Epub ahead of print]

Pharmacokinetics of imidocarb dipropionate in white-tailed deer (Odocoileus virginianus) after single intramuscular administration.

Author information

1
Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
2
Toronto Zoo, Toronto, Ontario, Canada.
3
Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
4
Veterinary Pharmacotherapeutics and Pharmacy Division, Faculty of Veterinary Medicine, Institute of Risk Assessment Science, Utrecht University, Utrecht, The Netherlands.

Abstract

This study was designed to investigate the pharmacokinetics of imidocarb, a carbanilide derivative, in white-tailed deer (Odocoileus virginianus). The pharmacokinetic properties of a single intramuscular (IM) dose of imidocarb were determined in 10 deer. A single IM injection of 3.0 mg/kg imidocarb dipropionate was administered, and blood samples were collected prior to, and up to 48 hr after imidocarb administration. Plasma imidocarb concentrations were determined by high-performance liquid chromatography with ultraviolet detection. The disposition of plasma imidocarb was best characterized by a two-compartment open model. The mean ± SE maximal imidocarb concentration in deer was 880.78 ± 81.12 ng/ml at 38.63 ± 5.30 min postinjection. The distribution phase had a half-life (t1/2α ) of 25.90 ± 10.21 min, and plasma imidocarb concentration declined with a terminal elimination half-life (t1/2β ) of 464.06 ± 104.08 min (7.73 ± 1.73 hr). Apparent volume of distribution based on the terminal phase (VZ /F) was 9.20 ± 2.70 L/kg, and apparent total body clearance (Cl/F) was 15.97 ± 1.28 ml min-1  kg-1 .

KEYWORDS:

Babesia ; Odocoileus virginianus ; cervid babesiosis; imidocarb dipropionate; white-tailed deer

PMID:
30933371
DOI:
10.1111/jvp.12760

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