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Retin Cases Brief Rep. 2019 Mar 28. doi: 10.1097/ICB.0000000000000866. [Epub ahead of print]

INVOLUTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AFTER ENDOPHTHALMITIS.

Author information

1
Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii.
2
The Retina Center at Pali Momi, Aiea, Hawaii.
3
Retina Consultants of Hawaii, Aiea, Hawaii.
4
Hawaii Macula and Retina Institute, Aiea, Hawaii.
5
John A. Burns School of Medicine, University of Hawaii School of Medicine, Honolulu, Hawaii.
6
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
7
Department of Ophthalmology, University of California San Francisco, Francis I. Proctor Foundation, San Francisco, California.
8
Columbia University College of Physicians and Surgeons, New York, New York.
9
Carolina Retina Center, Columbia, South Carolina.
10
VitreoRetinal Surgery, Minneapolis, Minnesota.

Abstract

PURPOSE:

To report patients who demonstrated an alteration in the clinical and optical coherence tomography features of neovascular age-related macular degeneration after resolution of endophthalmitis.

METHODS:

Retrospective case series of the subsequent changes in the macula and need for anti-vascular endothelial growth factor therapy in patients with neovascular age-related macular degeneration who developed endophthalmitis after intravitreal injection.

RESULTS:

The study included seven eyes of seven patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n = 7) before intravitreal antibiotic injection were the following: culture-negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (3). In 5/7 eyes, the optical coherence tomography showed resolution of subretinal fluid and serous pigment epithelial detachment, and there was no additional anti-vascular endothelial growth factor treatment administered.

CONCLUSION:

After successful treatment of endophthalmitis in patients with neovascular age-related macular degeneration, there was relative involution of the maculopathy and reduced anti-vascular endothelial growth factor treatment burden in this series.

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