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Nat Biomed Eng. 2019 Jan;3(1):47-57. doi: 10.1038/s41551-018-0336-5. Epub 2019 Jan 8.

Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow.

Author information

1
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
2
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
3
Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA.
4
Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
5
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA. pfox@stanford.edu.
6
Division of Plastic Surgery, Veterans Affairs Palo Alto, Palo Alto, CA, USA. pfox@stanford.edu.

Abstract

The ability to monitor blood flow is critical to patient recovery and patient outcomes after complex reconstructive surgeries. Clinically available wired implantable monitoring technology requires careful fixation for accurate detection and needs to be removed after use. Here, we report the design of a pressure sensor, made entirely of biodegradable materials and based on fringe-field capacitor technology, for measuring arterial blood flow in both contact and non-contact modes. The sensor is operated wirelessly through inductive coupling, has minimal hysteresis, fast response times, excellent cycling stability, is highly robust, allows for easy mounting and eliminates the need for removal, thus reducing the risk of vessel trauma. We demonstrate the operation of the sensor with a custom-made artificial artery model and in vivo in rats. This technology may be advantageous in real-time post-operative monitoring of blood flow after reconstructive surgery.

PMID:
30932072
DOI:
10.1038/s41551-018-0336-5
[Indexed for MEDLINE]

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