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Nat Biomed Eng. 2019 Jan;3(1):69-78. doi: 10.1038/s41551-018-0309-8. Epub 2018 Oct 22.

Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging.

Author information

1
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
2
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
3
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. jasanoff@mit.edu.
4
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. jasanoff@mit.edu.
5
Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. jasanoff@mit.edu.

Abstract

Biological electromagnetic fields arise throughout all tissue depths and types, and correlate with physiological processes and signalling in organs of the body. Most of the methods for monitoring these fields are either highly invasive or spatially coarse. Here, we show that implantable active coil-based transducers that are detectable via magnetic resonance imaging enable the remote sensing of biological fields. These devices consist of inductively coupled resonant circuits that change their properties in response to electrical or photonic cues, thereby modulating the local magnetic resonance imaging signal without the need for onboard power or wired connectivity. We discuss design parameters relevant to the construction of the transducers on millimetre and submillimetre scales, and demonstrate their in vivo functionality for measuring time-resolved bioluminescence in rodent brains. Biophysical sensing via microcircuits that leverage the capabilities of magnetic resonance imaging may enable a wide range of biological and biomedical applications.

PMID:
30932065
DOI:
10.1038/s41551-018-0309-8

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