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Nat Prod Res. 2019 Mar 31:1-9. doi: 10.1080/14786419.2019.1586702. [Epub ahead of print]

Antioxidant and anti-inflammatory constituents from Flos populi.

Author information

1
a Anhui Medical University , Hefei , China.
2
b Beijing Institute of Radiation Medicine , Beijing , China.
3
c College of Life Science and Bio-engineering, Beijing University of Technology , Beijing , China.

Abstract

Investigation of the n-butanol extract of Flos populi led to the isolation of one new phenolic glycoside, 4'-hydroxybenzyl-2-hydroxybenzoate-1'-O-β-D-glucopyranoside (1), together with twelve known compounds, which have been determined on the basis of spectroscopic analysis including UV, IR, HR-ESI-MS and 1D/2D NMR. The antioxidant capacity of all compounds were evaluated by ABTS radical-scavenging test and ferric reducing antioxidant power (FRAP) assay. And during a screening procedure for the anti-inflammatory activities among most compounds on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells, compound 13 exhibited remarkable inhibitory effects on nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β, suggesting that it might be a promising candidate as an anti-inflammatory agent.

KEYWORDS:

; anti-inflammatory activity; antioxidant property; new compound; phenolic glycoside

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