Application and design of esterase-responsive nanoparticles for cancer therapy

Haonan Dong; Long Pang; Hailin Cong; Youqing Shen; Bing Yu

doi:10.1080/10717544.2019.1588424

Application and design of esterase-responsive nanoparticles for cancer therapy

Drug Deliv. 2019 Dec;26(1):416-432. doi: 10.1080/10717544.2019.1588424.

Authors

Haonan Dong¹, Long Pang¹, Hailin Cong^{1

2}, Youqing Shen^{1

3}, Bing Yu^{1

2}

Affiliations

¹ a Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering , Qingdao University , Qingdao , Shandong , P.R. China.
² b State Key Laboratory of Bio-Fibers and Eco-Textiles , Qingdao University , Qingdao , Shandong , P.R. China.
³ c Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering , Zhejiang University , Hangzhou , Zhejiang , P.R. China.

Abstract

Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.

Keywords: Esterase-responsive nanoparticles; drug carriers; fluorescent imaging; gene therapy; photosensitizers.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / adverse effects
Antineoplastic Agents / pharmacology
Drug Delivery Systems
Drug Design
Esterases / metabolism
Humans
Nanoparticles*
Neoplasms / drug therapy*
Neoplasms / enzymology

Substances

Antineoplastic Agents
Esterases

Grants and funding

This work is financially supported by the National Natural Science Foundation of China [21675091, 21574072, 21874078], the Taishan Young Scholar Program of Shandong Province [tsqn20161027], the Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407], the Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111], the Natural Science Foundation of Shandong Province [ZR2017BEE010], the People’s Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh], the Innovation Leader Project of Qingdao [168325zhc], the Postdoctoral Scientific Research Foundation of Qingdao [40518060004], and the First Class Discipline Project of Shandong Province.