Effect of Hepatitis C Virus Coinfection on the Progression of Vertically Acquired Human Immunodeficiency Virus Infection During Childhood and Adolescence

Carolina Fernández-McPhee; Talía Sainz; María José Mellado; Antoni Noguera-Julian; Carmen Otero; Claudia Fortuny; Pere Soler-Palacín; María Dolores Falcón; José Tomás Ramos Amador; César Gavilán; María Isabel González-Tomé; María Luisa Navarro

doi:10.1093/jpids/piz008

Effect of Hepatitis C Virus Coinfection on the Progression of Vertically Acquired Human Immunodeficiency Virus Infection During Childhood and Adolescence

J Pediatric Infect Dis Soc. 2020 Apr 30;9(2):232-235. doi: 10.1093/jpids/piz008.

Authors

Carolina Fernández-McPhee^{1

2}, Talía Sainz³, María José Mellado^{4

5}, Antoni Noguera-Julian^{6

7

8}, Carmen Otero⁹, Claudia Fortuny^{6

7

8}, Pere Soler-Palacín¹⁰, María Dolores Falcón^{11

12}, José Tomás Ramos Amador^{13

14}, César Gavilán¹⁵, María Isabel González-Tomé¹⁶, María Luisa Navarro^{1

2}

Affiliations

¹ Departments of Pediatric Infectious Diseases, University Hospital Gregorio Marañón and Gregorio Marañón Research Institute (IiSGM), Madrid.
² Spain Universidad Complutense de Madrid, Spain.
³ Department of Pediatric Infectious Diseases, University Hospital La Paz and La Paz Research Institute (IdiPAZ), Madrid, Spain.
⁴ Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain.
⁵ Department of Pediatric Infectious Diseases, Universidad Autónoma de Madrid, Spain.
⁶ Unit of infectious Diseases and Systemic Inflammatory Response and Hospital Sant Joan de Déu Research Institute, Barcelona, Spain.
⁷ Department of Pediatrics, Universidad de Barcelona, Barcelona Spain.
⁸ CIBER in Epidemiology and Public Health, CIBERESP, Madrid, Spain.
⁹ Department of Pediatric Infectious Diseases, University Hospital La Fe, Valencia, Spain.
¹⁰ Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
¹¹ Pediatric Infectious Diseases, Immunology and Rheumatology Unit, University Hospital Virgen del Rocío, Sevilla, Spain.
¹² Pediatric Infectious Diseases, Immunology and Rheumatology Unit, Instituto de Biomedicina de Sevilla (IBiS), Spain.
¹³ Department of Pediatrics, Hospital Clinico San Carlos and Hospital Clinico San Carlos Research Institute, Madrid, Spain.
¹⁴ Department of Pediatrics, Universidad Complutense de Madrid, Madrid, Spain.
¹⁵ Department of Pediatrics, University Hospital Sant Joan d'Alacant, Alicante, Spain.
¹⁶ Pediatric Infectious Diseases and HIV Unit, University Hospital 12 de Octubre, Madrid, Spain.

PMID: 30929024
DOI: 10.1093/jpids/piz008

Abstract

Data for a total of 57 patients vertically coinfected with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) and 365 HIV-monoinfected patients were compared until their transition to adult care. No differences regarding the dynamics of CD4 and/or CD8 T-cell counts during childhood were found. The coexistence of HCV does not increase the risk of disease progression in vertically HIV-infected patients.

Keywords: HIV/HCV coinfection; children; disease progression; vertically acquired.

© The Author(s) 2019. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

Adolescent
Adult
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes
Child
Coinfection
Disease Progression
Female
HIV Infections / complications*
HIV Infections / immunology
HIV Infections / transmission
Hepacivirus
Hepatitis C / complications*
Humans
Infectious Disease Transmission, Vertical*
Male
Viral Load
Young Adult