Format

Send to

Choose Destination
Urology. 2019 Mar 28. pii: S0090-4295(19)30316-4. doi: 10.1016/j.urology.2019.03.019. [Epub ahead of print]

Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients.

Author information

1
Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: Bernardo.rocco@gmail.com.
2
Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy.
3
Data Methods and Systems Statistical Laboratory, University of Brescia, Brescia, Italy.
4
Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy; Urology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
5
Global Robotics Institute, Florida Hospital-Celebration Health Celebration, University of Central Florida School of Medicine, Orlando, FL.
6
Instituto do Câncer do Estado de São Paulo (Icesp), São Paulo, SP, Brazil.
7
Big & Open Data Innovation Laboratory, University of Brescia, Brescia, Italy.
8
Genitourinary Program, Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
9
Department of Urology, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Our aim was to review and externally validate all the available predictive tools (PTs) predicting extraprostatic extension (EPE) using the area under the curve, calibration plots, and scaled Brier score. A literature search was performed showing 19 models predicting EPE. External validation was carried out on 6360 prostate cancer patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration. The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients' counselling or for surgical strategy preplanning.

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center