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Trends Cell Biol. 2019 Mar 27. pii: S0962-8924(19)30028-5. doi: 10.1016/j.tcb.2019.02.006. [Epub ahead of print]

Multidimensional Single-Cell Analyses in Organ Development and Maintenance.

Author information

1
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
2
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; http://english.biomembrane.ioz.cas.cn/research/groups/liufeng. Electronic address: liuf@ioz.ac.cn.

Abstract

The revolution of single-cell analysis tools in epigenomics, transcriptomics, lineage tracing, and transcriptome-scale RNA imaging, has boosted our understanding of the underlying molecular mechanisms during organ development and maintenance. Application of these tools enables the multidimensional study of organs, from cell atlas profiling, spatial organization, to cell-cell interaction. Here, we discuss recent progress in employing multidimensional single-cell analyses to address fundamental questions related to the development and maintenance of hematopoietic organs, brain and lung, which will also help provide insights into a better understanding of relevant diseases.

KEYWORDS:

cell atlas; cell–cell interaction; organs; single-cell analysis; spatial organization

PMID:
30928527
DOI:
10.1016/j.tcb.2019.02.006

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