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FEBS J. 2019 Mar 30. doi: 10.1111/febs.14824. [Epub ahead of print]

MicroRNA 10a induces glioma tumorigenesis by targeting myotubularin-related protein 3 and regulating the Wnt/β-catenin signaling pathway.

Author information

1
Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huan Hu Hospital, China.

Abstract

MicroRNAs are involved in the regulation of tumor formation. A previous study suggested that miR-10a promotes glioma cell migration and invasion. However, the effect of miR-10a on the proliferation of glioma cells remains unknown. In this study, we demonstrated that miR-10a promoted proliferation and reduced apoptosis in glioma cells by directly targeting the 3'-UTR of myotubularin-related protein 3 (MTMR3). miR-10a enhanced, while MTMR3 weakened, the growth of glioma in vivo. Ectopic expression of MTMR3 neutralized the effect of miR-10a on glioma. Furthermore, miR-10a and MTMR3 regulated β-catenin expression and genes downstream of the Wnt/β-catenin signaling pathway, such as Bcl-2, c-myc, p-c-Jun, and cleaved caspase-3, to affect the proliferation ability and apoptosis of glioma cells. In conclusion, our results indicated that miR-10a regulated cell proliferation and apoptosis by directly targeting MTMR3 and could function as a prognostic factor for progression of glioma.

KEYWORDS:

B-cell lymphoma 2; Wnt/β-catenin signaling; apoptosis; microRNA; proliferation

PMID:
30927504
DOI:
10.1111/febs.14824

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