Send to

Choose Destination
FEBS J. 2019 Mar 30. doi: 10.1111/febs.14824. [Epub ahead of print]

MicroRNA 10a induces glioma tumorigenesis by targeting myotubularin-related protein 3 and regulating the Wnt/β-catenin signaling pathway.

Author information

Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huan Hu Hospital, China.


MicroRNAs are involved in the regulation of tumor formation. A previous study suggested that miR-10a promotes glioma cell migration and invasion. However, the effect of miR-10a on the proliferation of glioma cells remains unknown. In this study, we demonstrated that miR-10a promoted proliferation and reduced apoptosis in glioma cells by directly targeting the 3'-UTR of myotubularin-related protein 3 (MTMR3). miR-10a enhanced, while MTMR3 weakened, the growth of glioma in vivo. Ectopic expression of MTMR3 neutralized the effect of miR-10a on glioma. Furthermore, miR-10a and MTMR3 regulated β-catenin expression and genes downstream of the Wnt/β-catenin signaling pathway, such as Bcl-2, c-myc, p-c-Jun, and cleaved caspase-3, to affect the proliferation ability and apoptosis of glioma cells. In conclusion, our results indicated that miR-10a regulated cell proliferation and apoptosis by directly targeting MTMR3 and could function as a prognostic factor for progression of glioma.


B-cell lymphoma 2; Wnt/β-catenin signaling; apoptosis; microRNA; proliferation


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center