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Psychiatry Clin Neurosci. 2019 Jun;73(6):340-346. doi: 10.1111/pcn.12843. Epub 2019 Apr 22.

Association between delayed recall and T2* relaxation time of the subiculum in adolescents: Implications for ultra-high-field magnetic resonance imaging.

Author information

1
Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.
2
Department of Bioengineering, Gachon University of Medicine and Science, Incheon, Republic of Korea.
3
Department of Neurosurgery, Gachon University of Medicine and Science, Incheon, Republic of Korea.
4
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Abstract

AIM:

The aim of this study was to assess neuropsychological correlations with the T2* relaxation time (T2*-RT) of hippocampal subregions in adolescents using ultra-high-field (UHF) 7.0-T magnetic resonance imaging (MRI).

METHODS:

We assessed the T2*-RT of hippocampal subregions in 31 healthy 11th- or 12th-grade high school students using an UHF 7.0-T MRI system. T2*-RT of the cornu ammonis (CA) 1, CA2, CA3, and CA4 subregions and the subiculum were calculated for both the left and right hippocampus. Seven subtests of the Cambridge Neuropsychological Test Automated Battery were administered to the subjects to assess visuospatial memory.

RESULTS:

Poor performances in delayed recall in the pattern-recognition test were significantly correlated with longer T2*-RT in the bilateral subiculum (right, r = -0.480, P = 0.006; left, r = -0.648, P < 0.001) and the left CA2 (r = -0.480, P = 0.006).

CONCLUSION:

This study showed that longer T2*-RT in the subiculum were associated with poorer performances in delayed recall in the visual memory tasks. This finding suggests that the subiculum might play a predominant role in delayed recall in adolescents.

KEYWORDS:

adolescent; delayed recall; hippocampus; subiculum; ultra-high-field

PMID:
30927296
DOI:
10.1111/pcn.12843

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