Pathophysiology of Atrial Fibrillation and Heart Failure: Dangerous Interactions

Hariharan Sugumar; Shane Nanayakkara; Sandeep Prabhu; Aleksandr Voskoboinik; David M Kaye; Liang-Han Ling; Peter M Kistler

doi:10.1016/j.ccl.2019.01.002

Pathophysiology of Atrial Fibrillation and Heart Failure: Dangerous Interactions

Cardiol Clin. 2019 May;37(2):131-138. doi: 10.1016/j.ccl.2019.01.002. Epub 2019 Feb 20.

Authors

Hariharan Sugumar¹, Shane Nanayakkara², Sandeep Prabhu¹, Aleksandr Voskoboinik¹, David M Kaye², Liang-Han Ling³, Peter M Kistler⁴

Affiliations

¹ Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Cardiology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia.
² Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Medicine, Monash University, Victoria, 3800, Australia.
³ Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia.
⁴ Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia. Electronic address: peter.kistler@baker.edu.au.

PMID: 30926014
DOI: 10.1016/j.ccl.2019.01.002

Abstract

Atrial fibrillation and heart failure (HF) frequently coexist and are associated with a significant increase in morbidity and mortality. Despite the shared common risk factors atrial fibrillation and HF subtypes exacerbate each other. This review provides an overview of the pathophysiologic relationship between atrial fibrillation and the two most common types of heart failure syndromes: HF with reduced ejection fraction and HF with preserved ejection fraction.

Keywords: Atrial fibrillation; Cardiomyopathy; Diastolic dysfunction; HFpEF; HFrEF; Heart failure; Pathophysiology; Tachycardiomyopathy.

Publication types

Review

MeSH terms

Atrial Fibrillation / epidemiology
Atrial Fibrillation / physiopathology*
Comorbidity / trends
Global Health
Heart Failure / epidemiology
Heart Failure / physiopathology*
Heart Rate / physiology*
Humans
Prognosis
Risk Factors
Stroke Volume / physiology*