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BMC Complement Altern Med. 2019 Mar 29;19(1):77. doi: 10.1186/s12906-019-2483-y.

Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial.

Author information

1
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea.
2
Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Republic of Korea.
3
Chebegen Inc., Jeonju, Republic of Korea.
4
Healthcare Claims & Management Incorporation, Jeonju, Republic of Korea.
5
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea. swchae@jbctc.org.
6
Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Republic of Korea. swchae@jbctc.org.
7
Department of Pharmacology, Chonbuk National University, Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, 54896, Republic of Korea. swchae@jbctc.org.

Abstract

BACKGROUND:

Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults.

METHODS:

Healthy adults were divided into the intervention group (n = 39), who were given 1.68 g/day of CBG-CS-2 in capsules, and the control group (n = 40) for 8 weeks. The activities of natural killer (NK) cells and serum levels of monocyte-derived mediators were assessed initially for a baseline measurement and after 8 wks.

RESULTS:

The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from the baseline of NK cell cytotoxic activity relative to the placebo group after the administration of the capsules for 8 wks. (P < 0.019).

CONCLUSION:

The results suggest that the immune system functions well with CBG-CS-2 supplementation, perhaps with less accompanying inflammation. Thus, CBG-CS-2 is safe and effective for enhancing cell-mediated immunity in healthy adults.

TRIAL REGISTRATION:

This study was registered at Clinical Trials.gov ( NCT 02814617 ).

KEYWORDS:

Cordyceps; Immune; Mycelium culture; Natural killer (NK) cells; Paecilomyces hepiali

PMID:
30925876
PMCID:
PMC6441223
DOI:
10.1186/s12906-019-2483-y
[Indexed for MEDLINE]
Free PMC Article

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