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Int J Mol Sci. 2019 Mar 28;20(7). pii: E1563. doi: 10.3390/ijms20071563.

Contribution of Inflammatory Cytokine Interleukin-18 Genotypes to Renal Cell Carcinoma.

Author information

1
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. halittlemelon@hotmail.com.
2
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. chestshen@gmail.com.
3
Institute of New Drug Development, China Medical University, Taichung 40402, Taiwan. wlyeh@mail.cmu.edu.tw.
4
School of Pharmacy, China Medical University, Taichung 40402, Taiwan. ccyu@mail.cmu.edu.tw.
5
School of Pharmacy, China Medical University, Taichung 40402, Taiwan. hylin@mail.cmu.edu.tw.
6
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. wuhc@mail.cmuh.org.tw.
7
School of Medicine, China Medical University, Taichung 40402, Taiwan. wuhc@mail.cmuh.org.tw.
8
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. wenwen816@gmail.com.
9
Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan. artbau2@gmail.com.
10
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan. artbau2@gmail.com.
11
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan. artbau2@gmail.com.

Abstract

Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/C). Moreover, we analyzed their interactions with smoking, alcohol drinking, hypertension, and diabetes status. The results showed an association of the AC and CC genotypes of IL-18 -607 with a significant decrease in the risk of RCC compared with the AA genotype (odds ratio (OR) = 0.44 and 0.35, 95% confidence interval (CI) = 0.27⁻0.72 and 0.18⁻0.66, p = 0.0008 and 0.0010, respectively). Furthermore, a significantly lower frequency of the C allele at -607 was observed in the RCC group (35.3% vs. 49.8%; OR = 0.53; 95% CI = 0.35⁻0.71, p = 0.0003). However, IL-18 -656 and -137 did not exhibit a likewise differential distribution of these genotypes between the control and case groups. Stratifying the population according to smoking, alcohol drinking, hypertension, and diabetes status revealed a different distribution of IL-18 -607 genotypes among non-smokers, non-drinkers, and patients without diabetes, but not among smokers, drinkers, or patients with diabetes. These findings suggest that IL-18 -607 genotypes may play a role in the etiology and progression of RCC in Taiwan and may serve as a useful biomarker for early detection.

KEYWORDS:

IL-18; Taiwan; genotype; polymorphism; renal cell carcinoma

PMID:
30925760
PMCID:
PMC6479470
DOI:
10.3390/ijms20071563
[Indexed for MEDLINE]
Free PMC Article

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