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Curr Stem Cell Res Ther. 2019;14(6):495-503. doi: 10.2174/1574888X14666190329095638.

The Application of Neural Stem/Progenitor Cells for Regenerative Therapy of Spinal Cord Injury.

Yu C1,2, Xia K1,2, Gong Z1,2, Ying L1,2, Shu J1,2, Zhang F1,2, Chen Q1,2, Li F1,2, Liang C1,2.

Author information

1
Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jie Fang Road, Hangzhou 310009, Zhejiang, P.R. China.
2
Orthopedics Research Institute of Zhejiang University, No. 88, Jiefang Road, Hangzhou 310009, P.R. China.

Abstract

Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials have been widely investigated. In this review we aim to summarize the development and recent progress in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on sequential genetic steps regulating spinal cord development in vivo, we describe current experimental approaches for neural induction of NSCs in vitro. In particular, we focus on NSCs induced from pluripotent stem cells (PSCs). Finally, we highlight recent progress on the NSCs, which show great promise in the application to regeneration therapy for SCI.

KEYWORDS:

Spinal cord injury; macrophages; neural induction; neural stem cell; patient; pluripotent stem cell.

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