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J Pediatr Gastroenterol Nutr. 2019 Mar 26. doi: 10.1097/MPG.0000000000002343. [Epub ahead of print]

Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy.

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Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Comer Children's Hospital, University of Chicago Medical Center, Chicago, Illinois.
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Medical College of Wisconsin, Milwaukee, WI.
Division of Allergy and Immunology, Rush University Medical Center, Chicago, IL.
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Stead Family Children's Hospital, University of Iowa, Iowa City, IA.



The coexistence of celiac disease (CeD) and eosinophilic esophagitis (EoE) in pediatric patients has been increasingly recognized. In the current study, we have aimed to assess the outcomes of therapeutic dietary interventions in a cohort of pediatric patients with CeD and EoE.


Pediatric patient records obtained from the University of Chicago Celiac Center Database from August 2008 to July 2013 were reviewed. Information was collected on patients with concomitant CeD and EoE regarding age, gender, dates of diagnoses, presenting symptoms, length of symptoms prior to diagnosis, familial and personal atopic history, dietary therapy, and esophageal histologic response to dietary therapy.


A total of 350 records of CeD patients were reviewed. 22 (6.3%) had a confirmed diagnosis of CeD and EoE, 17 had repeat biopsies. 4/17 (23.5%) had resolution of esophageal eosinophilia on an exclusive gluten-free diet, 10/17 (59%) required additional eliminations to show histologic resolution, 1/17 (6%) hadn't reached histological remission, and 2/17 (12%) were lost to follow up. Success rates of single food reintroductions were: soy 5/5 (100%), eggs 3/5 (60%), dairy 3/7 (43%), nuts 2/4 (50%), and fish 2/4 (50%).


To our knowledge, this is the largest pediatric study to assess the histologic outcome of EoE-associated esophageal eosinophilia in response to dietary management of pediatric patients with concomitant CeD and EoE. We demonstrate that soy is well tolerated in this cohort, and suggest that reintroducing this food first, or trialing a soy-inclusive elimination diet is a viable strategy.

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