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J Interferon Cytokine Res. 2019 Aug;39(8):459-471. doi: 10.1089/jir.2019.0014. Epub 2019 Mar 28.

Inflammation and Immunity: From an Adipocyte's Perspective.

Author information

1
1Medical Scientist Training Program, Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
2
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
3
3Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
4
4Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
5
5Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
6
6Division of Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Abstract

Comprehension of adipocyte function has evolved beyond a long-held belief of their inert nature, as simple energy storing and releasing cells. Adipocytes, including white, brown, and beige, are capable mediators of global metabolic health, but their intersection with inflammation is a budding field of exploration. Evidence hints at a reciprocal relationship adipocytes share with immune cells. Adipocyte's capacity to behave in an "immune-like" manner and ability to sense inflammatory cues that subsequently alter core adipocyte function might play an important role in shaping immune responses. Clarifying this intricate relationship could uncover previously underappreciated contribution of adipocytes to inflammation-driven human health and disease. In this review, we highlight the potential of largely underappreciated adipocyte "immune-like" function and how it may contribute to inflammation, immunity, and pathology of various diseases.

KEYWORDS:

adipocytes; cytokines; inflammation; interferon; metabolism; obesity

PMID:
30920343
PMCID:
PMC6660836
DOI:
10.1089/jir.2019.0014

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