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Acta Paediatr. 2019 Mar 28. doi: 10.1111/apa.14798. [Epub ahead of print]

Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants.

Author information

1
Section for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
2
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
3
Sachs' Children and Youth Hospital, South General Hospital, Stockholm, Sweden.
4
Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
5
Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
6
Department of Ophthalmology, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.

Abstract

Leukocytosis, namely a markedly elevated white blood cell (WBC) count, occurs in 1.3-17.0% of infants admitted to neonatal intensive care units and can be induced by infection, inflammation, stress or medication. Postnatal leukocytosis can also reflect immature granulocytopoiesis in the bone marrow or systemic fetal inflammatory response syndrome, which particularly affects preterm infants (1). Chorioamnionitis and neonatal morbidities, such as sepsis, necrotising enterocolitis, intraventricular hemorrhage, prolonged oxygen support and bronchopulmonary dysplasia, have been associated with leukocytosis in preterm infants (2). This article is protected by copyright. All rights reserved.

PMID:
30920014
DOI:
10.1111/apa.14798

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