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Paediatr Child Health. 2018 Sep;23(6):403-419. doi: 10.1093/pch/pxy093. Epub 2018 Aug 16.

Evaluation of the child with global developmental delay and intellectual disability.

[Article in English, French]

Author information

1
Canadian Paediatric Society, Mental Health and Developmental Disabilities Committee, Ottawa, Ontario.

Abstract

Global developmental delay (GDD) and intellectual disability (ID) are common concerns in the paediatric setting. Etiologies of both conditions are highly heterogeneous. The American Academy of Pediatrics, the American Academy of Neurology and the British Columbia-based Treatable Intellectual Disability Endeavor (TIDE) protocol have each proposed multitiered investigations of GDD/ID to guide physicians toward an understanding of etiology that optimizes therapeutic yield. This statement provides a framework for the clinical investigation of GDD/ID in children, along with an updated protocol for Canadian physicians to follow in the etiological investigation of GDD/ID. The revised protocol is based on current knowledge and existing guidelines. Key elements of investigation include formal vision and hearing testing, chromosomal microarray, Fragile-X DNA testing and first-tier testing for treatable inborn errors of metabolism. Brain imaging is recommended in the presence of specific neurological findings.

KEYWORDS:

Chromosome microarray; Global developmental delay; IEM; Intellectual disability

PMID:
30919832
PMCID:
PMC6234423
[Available on 2019-09-01]
DOI:
10.1093/pch/pxy093

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