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World J Orthop. 2019 Mar 18;10(3):123-127. doi: 10.5312/wjo.v10.i3.123. eCollection 2019 Mar 18.

Linkage of microbiota and osteoporosis: A mini literature review.

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1
Department of Orthopedic Surgery, University of Toledo Medical Center, Toledo, OH 43614, United States.
2
Department of Orthopedic Surgery, University of Toledo Medical Center, Toledo, OH 43614, United States. jiayong.liu@utoledo.edu.

Abstract

The gut microbiota (GM) has become a recent topic of interest in the role of many disease states. Assessing patients with osteoporosis (OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation. Investigation of microbial profile relative to normal gut microbiomes, assessment of inflammatory markers such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha. Therapies to normalize GM in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant.

KEYWORDS:

Bone density; Gut microbiota; Linkage; Microbiota; Osteoporosis

Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

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