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Biochem J. 2019 Mar 27;476(6):1005-1008. doi: 10.1042/BCJ20190018.

Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.

Author information

1
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
2
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia preading@unimelb.edu.au.
3
WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia.

Abstract

Moloney leukemia virus 10 (MOV10) is an interferon-inducible RNA helicase that has been implicated in a broad range of cellular functions, including modulating the replication of a diverse range of viruses. However, the mechanisms by which MOV10 promotes or inhibits the replication of particular viruses have not been well defined. A recent paper published in the Biochemical Journal by Li et al. [Biochem. J. (2019) 476, 467-481] provides insight regarding the mechanisms by which MOV10 restricts influenza A virus (IAV) infection in host cells. First, the authors confirm that MOV10 binds to the viral nucleoprotein (NP) and sequesters the viral ribonucleoprotein complex in cytoplasmic granules called processing (P)-bodies, thus inhibiting IAV replication. Second, they demonstrate that the non-structural (NS)1 protein of IAV can act as an antagonist of MOV10, inhibiting the association of MOV10 with NP and promoting MOV10 degradation through the lysosomal pathway. Further research will determine if cellular RNA helicases such as MOV10 represent suitable targets for the development of novel anti-IAV therapies.

KEYWORDS:

RNA helicase; antiviral; influenza

PMID:
30918067
DOI:
10.1042/BCJ20190018

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