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Physiol Int. 2019 Mar 1;106(1):1-20. doi: 10.1556/2060.106.2019.07.

Regulation of Wnt signaling by physical exercise in the cell biological processes of the locomotor system.

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1 College of Physical Education and Sports Science, HengYang Normal University , Hengyang, Hunan, China.
2 Department of Neuroscience and Regenerative Medicine, Augusta University , Augusta, GA, USA.
3 Laboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University , Guangzhou, China.


In the past decade, researches on Wnt signaling in cell biology have made remarkable progress regarding our understanding of embryonic development, bone formation, muscle injury and repair, neurogenesis, and tumorigenesis. The study also showed that physical activity can reverse age-dependent decline in skeletal muscle, preventing osteoporosis, regenerative neurogenesis, hippocampal function, cognitive ability, and neuromuscular junction formation, and the age-dependent recession is highly correlated with Wnt signaling pathways. However, how the biological processes in cell and physical activity during/following exercise affect the Wnt signaling path of the locomotor system is largely unknown. In this study, we first briefly introduce the important features of the cellular biological processes of exercise in the locomotor system. Then, we discuss Wnt signaling and review the very few studies that have examined Wnt signaling pathways in cellular biological processes of the locomotor system during physical exercise.


Wnt signaling; cell biological processes; locomotor system; neuromuscular junction; physical exercise


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