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Int J Mol Sci. 2019 Mar 26;20(6). pii: E1520. doi: 10.3390/ijms20061520.

Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma.

Author information

1
University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland. cristina.porcheri@zzm.uzh.ch.
2
University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland. christian.meisel@zzm.uzh.ch.
3
University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland. thimios.mitsiadis@zzm.uzh.ch.

Abstract

Head and neck squamous cell carcinoma (HNSCC) defines a group of solid tumors originating from the mucosa of the upper aerodigestive tract, pharynx, larynx, mouth, and nasal cavity. It has a metastatic evolution and poor prognosis and is the sixth most common cancer in the world, with 600,000 new cases reported every year. HNSCC heterogeneity and complexity is reflected in a multistep progression, involving crosstalk between several molecular pathways. The Notch pathway is associated with major events supporting cancerogenic evolution: cell proliferation, self-renewal, angiogenesis, and preservation of a pro-oncogenic microenvironment. Additionally, Notch is pivotal in tumor development and plays a dual role acting as both oncogene and tumor suppressor. In this review, we summarize the role of the Notch pathway in HNSCC, with a special focus on its compelling role in major events of tumor initiation and growth.

KEYWORDS:

Notch pathway; oral cancer; squamous cell carcinoma

PMID:
30917608
PMCID:
PMC6471940
DOI:
10.3390/ijms20061520
[Indexed for MEDLINE]
Free PMC Article

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