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Br J Haematol. 2019 Mar 27. doi: 10.1111/bjh.15887. [Epub ahead of print]

The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.

Author information

1
Institut de Recerca contra la Leucemia Josep Carreras, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
2
Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Badalona, Spain.
3
Institut de Recerca contra la Leucemia Josep Carreras, Hospital Sant Pau, Barcelona, Spain.
4
Institut Català d'Oncologia, Hospital Joan XXIII, Tarragona, Spain.
5
Hospital La Fe, Valencia, Spain.
6
Institut Català d'Oncologia, Hospital Duran i Reynals, Hospitalet de Llobregat, Llobregat, Spain.
7
Institut Català d'Oncologia, Hospital Josep Trueta, Girona, Spain.
8
Hospital Universitario Virgen del Rocío, Sevilla, Spain.
9
Hospital del Mar, Barcelona, Spain.
10
Hospital Vall d'Hebron, Barcelona, Spain.
11
Hospital Marqués de Valdecilla, Santander, Spain.
12
Hospital General de Alicante, Alicante, Spain.
13
Hospital Clínico, Valencia, Spain.
14
Hospital Doctor Peset, Valencia, Spain.
15
Hospital Universitario Central de Asturias, Oviedo, Spain.
16
Hospital Universitario de Salamanca, Universidad de Salamanca, IBMCC (CSIC/USAL), IBSAL and CIBERONC, Salamanca, Spain.
17
Hospital Doce de Octubre, Madrid, Spain.
18
Institut de Recerca contra la Leucemia Josep Carreras, Hospital Clínic, Barcelona, Spain.
19
Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.
20
Hospital Arnau de Vilanova, Lleida, Spain.
21
Hospital Juan Canalejo, A Coruña, Spain.
22
Hospital Clínico Universitario Virgen de la Arrixaca, IMIB, Universidad de Murcia, Murcia, Spain.
23
Hospital General de Segovia, Segovia, Spain.
24
Hospital Verge de la Cinta, Tortosa, Spain.
25
Hospital Virgen de la Victoria, Málaga, Spain.

Abstract

The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

KEYWORDS:

acute lymphoblastic leukaemia; adults; age; hypodiploidy; prognosis

PMID:
30916384
DOI:
10.1111/bjh.15887

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