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Life Sci. 2019 May 1;224:109-119. doi: 10.1016/j.lfs.2019.03.055. Epub 2019 Mar 23.

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease.

Author information

1
Faculty of Bioscience and Agri-Food and Environmental Technology, University of Teramo, 64100, Italy.
2
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.
3
Department of Pathology, Faculty of Veterinary Science, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur 63100, Pakistan.
4
Department of Pharmacy, Southeast University Dhaka, Bangladesh.
5
Department of Pharmacology and Toxicology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur 63100, Pakistan. Electronic address: kniaz@unite.it.

Abstract

Quercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmonary, schizophrenia and cardiovascular diseases. Quercetin possesses scavenging potential of hydroxyl radical (OH-), hydrogen peroxide (H2O2), and superoxide anion (O2-). These reactive oxygen species (ROS) hampers lipid, protein, amino acids and deoxyribonucleic acid (DNA) processing leading to epigenetic alterations. Quercetin has the ability to combat these harmful effects. ROS plays a vital role in the progression of Alzheimer's disease (AD), and we propose that quercetin would be the best choice to overcome cellular and molecular signals in regulating normal physiological functions. However, data are not well documented regarding exact cellular mechanisms of quercetin. The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways. Therefore, the aim of the present review was to elaborate on the cellular and molecular mechanisms of the quercetin involved in the protection against AD.

KEYWORDS:

Alzheimer's disease; Oxidative stress; Quercetin; Reactive oxygen species

PMID:
30914316
DOI:
10.1016/j.lfs.2019.03.055

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